I think one of the most fun tasks a material artist can get are those, than can convert a time consuming task into a very quick one. To me, this is where a node-based, non-destructive Substance Designer workflow really shines.
This particular substance was the result of being tasked with creating a workflow that would automatically convert any photo (or any graphics) into an "oil paint-like" canvas.
Top left corner is the input picture and top right corner is the result. Bottom right corner shows example photos, that were used as inputs, with some additional tweaks.
Rendered in Marmoset